H-2 and HLA sequences
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چکیده
منابع مشابه
PREPARATION AND CHARACTERIZATION OF [Ni (MAP) ] ; H- MAP = 2- (METHYLAMINO) PYRIDINE H. Aghabozorg* and H. H. Monfared
We have recently synthesized [Ni (MAP) ] complex [H-MAP= 2- (methylamino) pyridine]. 2- (Methy1amino)pyridine reacts with MeLi in THF and generates the lithium salt (Li-MAP). Further reaction of NiCl with two equivalent of this ligand in THF leads to the formation of a dark red solution. Analytical data, molecular weight, and magnetic susceptibility of this complex confirm the formula [N...
متن کاملComparative analysis of the CD8(+) T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice.
HHD transgenic mice which express HLA-A2.1 monochain molecules in a H-2 class I(-) context have an improved capacity to develop HLA-A2.1-restricted cytotoxic T lymphocyte (CTL) responses as compared with classical A2.1/K(b) transgenic mice, which express heterodimeric HLA-A2.1 molecules in a H-2 class I wild-type context. A detailed TCR analysis of HLA-A2.1-restricted CD8(+) T cells educated an...
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HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. It is known that DM interaction with MHC II involves conformational changes in the MHC II molecule leading to the disturbance of H-bonds formed between the bound peptide and the MHC II groove leading to peptide dissociation. The specific region of the DM mo...
متن کاملPotentially H-bigraphic sequences
We extend the notion of a potentially H-graphic sequence as follows. Let A and B be nonnegative integer sequences. The sequence pair S = (A,B) is said to be bigraphic if there is some bipartite graph G = (X ∪ Y, E) such that A and B are the degrees of the vertices in X and Y , respectively. If S is a bigraphic pair, let σ(S) denote the sum of the terms in A. Given a bigraphic pair S, and a fixe...
متن کاملClustering and Alignment of Polymorphic Sequences for HLA-DRB1 Genotyping
Located on Chromosome 6p21, classical human leukocyte antigen genes are highly polymorphic. HLA alleles associate with a variety of phenotypes, such as narcolepsy, autoimmunity, as well as immunologic response to infectious disease. Moreover, high resolution genotyping of these loci is critical to achieving long-term survival of allogeneic transplants. Development of methods to obtain high reso...
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ژورنال
عنوان ژورنال: Nature
سال: 1976
ISSN: 0028-0836,1476-4687
DOI: 10.1038/261189a0